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Clopra

Generic name: Metoclopramide Hydrochloride

Brand names: Reglan, Primperan, Clopra, Maxolon, Metoclopramide

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Why is Clopra prescribed?

Clopra increases the contractions of the stomach and small intestine, helping the passage of food. It is given to treat the symptoms of diabetic gastroparesis, a condition in which the stomach does not contract. These symptoms include vomiting, nausea, heartburn, feeling of indigestion, persistent fullness after meals, and appetite loss. Clopra is also used, for short periods, to treat heartburn in people with gastroesophageal reflux disorder (backflow of stomach contents into the esophagus). In addition, it is given to prevent nausea and vomiting caused by cancer chemotherapy and surgery.

Most important fact about Clopra

Clopra may cause mild to severe depression. If you have suffered from depression in the past, make sure your doctor is aware of it. Clopra may not be the best drug for you.

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How should you take Clopra?

Clopra is usually taken 30 minutes before a meal. If you suffer from heartburn that occurs only intermittently or only at certain times of day, your doctor may want you to schedule your Clopra therapy around those times.

You will probably take Clopra for only 4 to 12 weeks. Continuous treatment beyond 12 weeks is not recommended.

If you have diabetic "lazy stomach" (gastric stasis) that tends to recur, your doctor may want you to take Clopra at the first sign of a recurrence.

If you miss a dose of Clopra

Take Clopra as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.

Storage instructions for Clopra

Store at room temperature.

What side effects when taking Clopra may occur?

Side effects cannot be anticipated with Clopra. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Clopra.

More common side effects when taking Clopra may include:

Drowsiness, fatigue, restlessness

Less common or rare side effects when taking Clopra may include:

Breast development in males, confusion, congestive heart failure, continual discharge of milk from the breasts, depression, diarrhea, dizziness, fluid retention, frequent urination, hallucinations, headache, high or low blood pressure, high fever, hives, impotence, inability to hold urine, insomnia, menstrual irregularities, nausea, rapid or slow heartbeat, rash, rigid muscles, slow movement, swollen tongue or throat, tremor, vision problems, wheezing, yellowed eyes and skin
In addition, Clopra may cause symptoms similar to those of Parkinson's disease, such as slow movements, rigidity, tremor, or a mask-like facial appearance.

Especially in older people, Clopra may produce tardive dyskinesia, a syndrome of jerky or writhing involuntary movements, particularly of the tongue, face, mouth, or jaw. In children and adults under 30, Clopra may cause involuntary movements of the arms and legs, and sometimes loud or labored breathing, usually in the first day or two of treatment.

Clopra may cause intense restlessness with associated symptoms such as anxiety, agitation, foot-tapping, pacing, inability to sit still, jitteriness, and insomnia. These symptoms may disappear as your body gets used to Clopra, or if your dosage is reduced.

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Why should Clopra not be prescribed?

Do not take Clopra if you are sensitive to it or have ever had an allergic reaction to Clopra..

You should not take Clopra if you have a condition such as obstruction, perforation, or hemorrhage of the stomach or small bowel that might be aggravated by increased stomach and small-bowel movement.

If you have pheochromocytoma (a nonmalignant tumor that causes hypertension), do not take Clopra; it could trigger a dangerous jump in blood pressure.

Do not take Clopra if you have epilepsy; it could increase the frequency and severity of seizures.

If you are taking a drug that is likely to cause side effects such as tremors, jerks, grimaces, or writhing movements, do not take Clopra; it could make such symptoms more severe.

Clopra is not recommended for patients under 18 years of age.

Special warnings about Clopra

If you have Parkinson's disease, you should be given Clopra cautiously or not at all, since the drug may make your Parkinson's symptoms worse.

Because Clopra may make you drowsy and impair your coordination, you should not drive, climb, or perform hazardous tasks until you know how the medication affects you.

Use Clopra with caution if you have high blood pressure. Be careful, too, if you have cirrhosis or congestive heart failure. Under these conditions, Clopra may cause fluid retention and heart problems. If this happens during the first few weeks of Clopra therapy, you'll have to stop taking Clopra.

Possible food and drug interactions when taking Clopra

If Clopra is taken with certain other drugs, the effects of either could be increased, decreased, or altered.

It is especially important to check with your doctor before combining Clopra with the following:

Acetaminophen (Tylenol)
Alcoholic beverages
Antispasmodic drugs such as Bentyl and Pro-Banthine
Cimetidine (Tagamet)
Cyclosporine (Sandimmune)
Digoxin (Lanoxin)
Insulin
MAO inhibitor antidepressants such as Nardil and Parnate
Levodopa (Sinemet)
Narcotic painkillers such as Percocet and Demerol
Sleeping pills such as Dalmane, Halcion, and Restoril
Tetracycline (Sumycin, others)
Tranquilizers such as Valium and Xanax

If you take insulin for diabetes, your insulin dosage or dosing schedule may have to be adjusted while you are taking Clopra.

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Special information if you are pregnant or breastfeeding

The effects of Clopra during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Clopra should be used during pregnancy only if it is clearly needed. Clopra appears in breast milk. Your doctor may recommend that you discontinue Clopra while you are breastfeeding your baby.

Recommended dosages for Clopra

ADULTS

Symptoms of Gastroesophageal Reflux
The usual dose is 10 milligrams to 15 milligrams of Clopra, up to 4 times a day, 30 minutes before each meal and at bedtime, depending upon the symptoms being treated and the effectiveness of the dose. Treatment usually lasts no longer than 12 weeks.

If symptoms occur only intermittently or at specific times of the day, your doctor may give you a single dose of up to 20 milligrams as a preventive measure.

Symptoms Associated with Diabetic Gastroparesis or Gastric Stasis

The usual dose is 10 milligrams 30 minutes before each meal and at bedtime for 2 to 8 weeks.

OLDER ADULTS

Relief of Symptomatic Gastroesophageal Reflux
Older adults may need only 5 milligrams per dose.

Overdosage with Clopra

Any medication taken in excess can have serious consequences. If you suspect an overdose of Clopra, seek medical attention immediately.

Symptoms of Clopra overdose may include:

Disorientation, drowsiness, involuntary movements

 

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