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Imitrex

Generic name: Sumatriptan Succinate

 

Why is Imitrex prescribed?

Imitrex is prescribed for the treatment of a migraine attack with or without the presence of an aura (visual disturbances, usually sensations of halos or flickering lights, which precede an attack). The injectable form is also used to relieve cluster headache attacks. (Cluster headaches come on in waves, then disappear for long periods of time. They are limited to one side of the head, and occur mainly in men.) Imitrex cuts headaches short. It will not reduce the number of attacks you experience.

Most important fact about Imitrex

Imitrex should be used only to treat an acute, classic migraine attack or a cluster headache. It should not be used for certain unusual types of migraine.

How should you take Imitrex?

Imitrex should be taken as soon as your symptoms appear, but may be used at any time during an attack. It is available in three forms: injection, tablets, and nasal spray.

Imitrex tablets should be swallowed whole, with liquid. If you have had no relief 2 hours after taking Imitrex Tablets, you may take a second dose of up to 100 milligrams, if your doctor advises it. If the headache returns, you may take additional doses at intervals of at least 2 hours. You should not take more than 300 milligrams in one day. If your headache returns after you have had an Imitrex Injection, you may take single Imitrex Tablets, at intervals of at least 2 hours, up to a maximum of 200 milligrams in a day.

If you miss a dose of Imitrex

Imitrex is not for regular use. Take it only during an attack.

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Storage instructions for Imitrex

Store Imitrex away from heat and light, at room temperature, in the case provided. If your Imitrex has expired (the expiration date is printed on the treatment pack), throw it away as instructed. If your doctor decides to stop your treatment, do not keep any leftover Imitrex unless your doctor tells you to. Throw away your Imitrex as instructed.

What side effects when taking Imitrex may occur?

Side effects with Imitrex cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Imitrex.

More common side effects when taking Imitrex may include:

Burning sensation, dizziness or vertigo, feeling of heaviness, feeling of tightness, flushing, mouth and tongue discomfort, muscle weakness, nausea (nasal spray), neck pain and stiffness, numbness, pressure sensation, redness at the site of injection, sinus or nasal discomfort (nasal spray), sore throat, tingling, unusual taste (nasal spray), vomiting (nasal spray), warm/cold sensation.

Less common or rare side effects when taking Imitrex may include:

Abdominal discomfort, agitation, allergic reactions (severe), anxiety, asthma, backache, backflow of stomach contents, bleeding between periods, bleeding in ears, nose or throat, breast tenderness, burning/numbness of tongue, changes in heart rhythm, chills, cold sensation, confusion, constipation, cough, depression, diarrhea, difficult or labored breathing, difficult or painful urination, difficulty concentrating, difficulty speaking, difficulty swallowing, drowsiness/calmness, dry mouth, ear infection, ear pain, exaggerated feeling of well-being, eye irritation, facial pain, fainting, fatigue, feeling strange, fever, general feeling of illness, headache, hearing loss, hearing disturbance, heavy feeling, hives, incoordination, increased urination, intolerance of noise or light, itching, jaw discomfort, joint problems, muscle cramps, muscle pain or tenderness, painful menstruation, pressure in chest, rapid and throbbing heartbeat, rash, ringing in the ears, rise or fall in blood pressure (temporary), sensation of lightness, sensitivity to noise or heat, shivering, shortness of breath, sinus inflammation, sinus or nasal discomfort, skin eruptions, skin redness or tenderness, sleep disturbances, smell disturbances, stomach problems, sweating, swelling, tearing, thirst, tight feeling in head, tightness in chest, tremors, vision changes or loss. In addition to the above side effects, people taking Imitrex for cluster headache may experience nausea, a "pins and needles" sensation, vomiting, or wheezing.

Why should Imitrex not be prescribed?

Imitrex should not be used for the hemiplegic or basilar forms of migraine. You must also avoid Imitrex if it gives you an allergic reaction.

In addition, Imitrex should not be prescribed if you have certain types of heart or blood vessel disease, including angina (crushing chest pain) or a history of heart attack, stroke, mini-strokes, or other circulatory problems. It should not be used if you have severe liver disease or uncontrolled high blood pressure. It must not be used within 24 hours of taking an ergotamine-based migraine remedy (such as D.H.E. 45 Injection or Sansert) or any drug in the same class as Imitrex (such as Amerge, Maxalt, or Zomig). And it must not be used for 2 weeks after taking an MAO inhibitor drug such as the antidepressants Nardil and Parnate.

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Special warnings about Imitrex

Although the danger is minimal, Imitrex has triggered serious heart problems in people with heart disease. For that reason, the doctor may want you to take your first dose of Imitrex in the office, where you can be closely watched for ill effects.

Be sure to tell the doctor if you have any conditions that increase your risk of heart disease, such as high blood pressure, high cholesterol, or diabetes. Also let him know if you smoke, have heart disease in the family, or have gone through menopause. Patients at risk of heart disease should have periodic cardiac evaluations as long as they continue using Imitrex. If you develop pain or tightness in the chest, throat, or jaw after taking a dose, consult your doctor before taking any more.

If you develop severe chest pain, call the doctor immediately. Also seek immediate attention if you suffer sudden, severe abdominal pain after a dose of Imitrex. It could signal a blood vessel problem.

If your fingers turn pale, then blue, after a dose of Imitrex, you may have a circulatory problem such as hardening of the arteries. Be sure to let your doctor know.

Imitrex should not be used for other types of migraine headache. If the first dose does not relieve your symptoms, your doctor will re-evaluate you; you may not have migraine or cluster headache.

If your headache does not feel like any you have been experiencing, do not take Imitrex.

Use Imitrex cautiously if you have liver or kidney disease. Also, if you have any trouble with your eyes, tell your doctor.

Imitrex is not recommended for adults over 65. It has not been tested in children.

Although very rare, severe and even fatal allergic reactions have occurred in people taking Imitrex. Such reactions are more likely in people who have several allergies. In rare cases, people have suffered seizures after taking Imitrex.

Possible food and drug interactions when taking Imitrex

If Imitrex is taken with certain other drugs, the effects of either may be increased, decreased, or altered.

It is important to check with your doctor before combining Imitrex with the following:

Drugs classified as MAO inhibitors, including the antidepressants Nardil and Parnate
Ergot-containing drugs such as Cafergot and Ergostat
Fluoxetine (Prozac)
Fluvoxamine (Luvox)
Paroxetine (Paxil)
Sertraline (Zoloft)

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Special information if you are pregnant or breastfeeding

The effects of Imitrex during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Imitrex does appear in breast milk and could affect a nursing infant. If Imitrex is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with Imitrex is finished.

Recommended dosages for Imitrex

The usual adult dose is one 25, 50, or 100 milligram tablet taken with water or other liquid. The most you should take at one time is 100 milligrams, and the most you should take in 1 day is 200 milligrams. Doses should be spaced at least 2 hours apart.

If you have liver disease, you should not take more than 50 milligrams of Imitrex Tablets at one time.

Overdosage with Imitrex

Any medication taken in excess can have serious consequences. If you suspect an overdose of Imitrex, seek medical attention immediately.

Symptoms of Imitrex overdose may include:

Bluish tinge to the skin, convulsions, dilated pupils, inactivity, lack of coordination, paralysis, redness in the arms and legs, skin changes at the site of injection, slow breathing, sluggishness, tremor.

 

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