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Maxolon

Generic name: Metoclopramide Hydrochloride

Brand names: Reglan,Primperan, Clopra, Maxolon, Metoclopramide

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Why is Maxolon prescribed?

Maxolon increases the contractions of the stomach and small intestine, helping the passage of food. It is given to treat the symptoms of diabetic gastroparesis, a condition in which the stomach does not contract. These symptoms include vomiting, nausea, heartburn, feeling of indigestion, persistent fullness after meals, and appetite loss. Maxolon is also used, for short periods, to treat heartburn in people with gastroesophageal reflux disorder (backflow of stomach contents into the esophagus). In addition, it is given to prevent nausea and vomiting caused by cancer chemotherapy and surgery.

Most important fact about Maxolon

Maxolon may cause mild to severe depression. If you have suffered from depression in the past, make sure your doctor is aware of it. Maxolon may not be the best drug for you.

How should you take Maxolon?

Maxolon is usually taken 30 minutes before a meal. If you suffer from heartburn that occurs only intermittently or only at certain times of day, your doctor may want you to schedule your Maxolon therapy around those times.

You will probably take Maxolon for only 4 to 12 weeks. Continuous treatment beyond 12 weeks is not recommended.

If you have diabetic "lazy stomach" (gastric stasis) that tends to recur, your doctor may want you to take Maxolon at the first sign of a recurrence.

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If you miss a dose of Maxolon

Take Maxolon as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.

Storage instructions for Maxolon

Store at room temperature.

What side effects when taking Maxolon may occur?

Side effects cannot be anticipated with Maxolon. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Maxolon.

More common side effects when taking Maxolon may include:

Drowsiness, fatigue, restlessness

Less common or rare side effects when taking Maxolon may include:

Breast development in males, confusion, congestive heart failure, continual discharge of milk from the breasts, depression, diarrhea, dizziness, fluid retention, frequent urination, hallucinations, headache, high or low blood pressure, high fever, hives, impotence, inability to hold urine, insomnia, menstrual irregularities, nausea, rapid or slow heartbeat, rash, rigid muscles, slow movement, swollen tongue or throat, tremor, vision problems, wheezing, yellowed eyes and skin
In addition, Maxolon may cause symptoms similar to those of Parkinson's disease, such as slow movements, rigidity, tremor, or a mask-like facial appearance.

Especially in older people, Maxolon may produce tardive dyskinesia, a syndrome of jerky or writhing involuntary movements, particularly of the tongue, face, mouth, or jaw. In children and adults under 30, Maxolon may cause involuntary movements of the arms and legs, and sometimes loud or labored breathing, usually in the first day or two of treatment.

Maxolon may cause intense restlessness with associated symptoms such as anxiety, agitation, foot-tapping, pacing, inability to sit still, jitteriness, and insomnia. These symptoms may disappear as your body gets used to Maxolon, or if your dosage is reduced.

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Why should Maxolon not be prescribed?

Do not take Maxolon if you are sensitive to it or have ever had an allergic reaction to Maxolon.

You should not take Maxolon if you have a condition such as obstruction, perforation, or hemorrhage of the stomach or small bowel that might be aggravated by increased stomach and small-bowel movement.

If you have pheochromocytoma (a nonmalignant tumor that causes hypertension), do not take Maxolon; it could trigger a dangerous jump in blood pressure.

Do not take Maxolon if you have epilepsy; it could increase the frequency and severity of seizures.

If you are taking a drug that is likely to cause side effects such as tremors, jerks, grimaces, or writhing movements, do not take Maxolon; it could make such symptoms more severe.

Maxolon is not recommended for patients under 18 years of age.

Special warnings about Maxolon

If you have Parkinson's disease, you should be given Maxolon cautiously or not at all, since the drug may make your Parkinson's symptoms worse.

Because Maxolon may make you drowsy and impair your coordination, you should not drive, climb, or perform hazardous tasks until you know how the medication affects you.

Use Maxolon with caution if you have high blood pressure. Be careful, too, if you have cirrhosis or congestive heart failure. Under these conditions, Maxolon may cause fluid retention and heart problems. If this happens during the first few weeks of Maxolon therapy, you'll have to stop taking Maxolon.

Possible food and drug interactions when taking Maxolon

If Maxolon is taken with certain other drugs, the effects of either could be increased, decreased, or altered.

It is especially important to check with your doctor before combining Maxolon with the following:

Acetaminophen (Tylenol)
Alcoholic beverages
Antispasmodic drugs such as Bentyl and Pro-Banthine
Cimetidine (Tagamet)
Cyclosporine (Sandimmune)
Digoxin (Lanoxin)
Insulin
MAO inhibitor antidepressants such as Nardil and Parnate
Levodopa (Sinemet)
Narcotic painkillers such as Percocet and Demerol
Sleeping pills such as Dalmane, Halcion, and Restoril
Tetracycline (Sumycin, others)
Tranquilizers such as Valium and Xanax

If you take insulin for diabetes, your insulin dosage or dosing schedule may have to be adjusted while you are taking Maxolon.

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Special information if you are pregnant or breastfeeding

The effects of Maxolon during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Maxolon should be used during pregnancy only if it is clearly needed. Maxolon appears in breast milk. Your doctor may recommend that you discontinue Maxolon while you are breastfeeding your baby.

Recommended dosages for Maxolon

ADULTS

Symptoms of Gastroesophageal Reflux
The usual dose is 10 milligrams to 15 milligrams of Maxolon, up to 4 times a day, 30 minutes before each meal and at bedtime, depending upon the symptoms being treated and the effectiveness of the dose. Treatment usually lasts no longer than 12 weeks.

If symptoms occur only intermittently or at specific times of the day, your doctor may give you a single dose of up to 20 milligrams as a preventive measure.

Symptoms Associated with Diabetic Gastroparesis or Gastric Stasis

The usual dose is 10 milligrams 30 minutes before each meal and at bedtime for 2 to 8 weeks.

OLDER ADULTS

Relief of Symptomatic Gastroesophageal Reflux
Older adults may need only 5 milligrams per dose.

Overdosage with Maxolon

Any medication taken in excess can have serious consequences. If you suspect an overdose of Maxolon, seek medical attention immediately.

Symptoms of Maxolon overdose may include:

Disorientation, drowsiness, involuntary movements

 

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