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Mirtazapine

Brand names: Remeron, Mirtazapina

Generic name: Mirtazapine


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Why is Mirtazapine prescribed?

Mirtazapine is prescribed for the treatment of major depression- that is, a continuous depressed mood that interferes with everyday life. The symptoms of major depression often include changes in appetite and weight, difficulty sleeping, loss of interest in pleasurable activities, constant fidgeting or a slowdown in movement, fatigue, feelings of guilt or worthlessness, difficulty concentrating, slowed thinking, and suicidal thoughts.

Mirtazapine is thought to work by adjusting the balance of the brain's natural chemical messengers, especially norepinephrine and serotonin.

Most important fact about Mirtazapine

Mirtazapine makes some people drowsy or less alert, and may affect judgment and thinking. Don't drive or participate in any hazardous activity that requires full mental alertness until you know whether Mirtazapine has this effect on you.

How should you take Mirtazapine?

Mirtazapine may be taken with or without food. It is preferable to take it in the evening before you go to sleep. Even though you may begin to feel better in 1 to 4 weeks, continue taking Mirtazapine exactly as prescribed. Regular daily doses are needed for the drug to work properly.

If you are using Mirtazapine SolTabs, an orally disintegrating form of the drug, make sure your hands are dry before removing the tablet from the blister pack and immediately place the tablet on your tongue. Do not attempt to split the tablet; it will fall apart rapidly and can be swallowed with saliva.

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If you miss a dose of Mirtazapine

Take the forgotten dose if you remember within a few hours. Otherwise, skip the dose. Never try to "catch up" by doubling the dose.

Storage instructions for Mirtazapine

Store at room temperature in a tight, light-resistant container.

What side effects may occur when taking Mirtazapine?

Side effects of Mirtazapine cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Mirtazapine.

More common side effects of taking Mirtazapine may include:
Abnormal dreams and thinking, constipation, dizziness, dry mouth, "flu-like" symptoms, increased appetite, sleepiness, weakness, weight gain

Less common side effects of taking Mirtazapine may include:
Back pain, confusion, difficult or labored breathing, fluid retention, frequent urination, muscle pain, nausea, swelling of ankles or hands, tremors

Why should Mirtazapine not be prescribed?

If you have ever had an allergic reaction to Mirtazapine or similar drugs such as Ludiomil and Desyrel, you should not take Mirtazapine. Be sure to tell your doctor about any drug reactions you have experienced.

You should also avoid Mirtazapine if you are taking the antidepressants Nardil or Parnate.

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Special warnings about Mirtazapine

Serious, sometimes fatal reactions have been known to occur when drugs such as Mirtazapine are taken in combination with other drugs known as MAO inhibitors, including the antidepressants Nardil and Parnate. Never take Mirtazapine with one of these drugs or within 14 days of discontinuing therapy with one of them; and allow at least 14 days between stopping Mirtazapine and starting an MAO inhibitor.

If you develop "flu-like" symptoms, a sore throat, chills or fever, mouth sores, or any other signs of infection, call your doctor; these symptoms may signal a serious underlying condition.

Mirtazapine tends to raise cholesterol levels in some people. If you have a cholesterol problem, be sure to mention it to your doctor before starting therapy with Mirtazapine.

Mirtazapine should be used with caution if you have active liver or kidney disease, or heart or blood pressure problems. Also be sure to tell your doctor if you have a history of seizures, mania (extremely high spirits), hypomania (mild excitability), drug use, or any other physical or emotional problems.

While first taking Mirtazapine you may feel dizzy or light-headed, especially when getting up from a lying or sitting position. If getting up slowly doesn't help, or if this problem continues, notify your doctor.

If you must avoid phenylalanine, do not use the SolTab form of Mirtazapine, which contains this substance.

Possible food and drug interactions when taking Mirtazapine

Never combine Mirtazapine with an MAO inhibitor; and do not drink alcohol while taking this medication. If Mirtazapine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Mirtazapine with tranquilizers such as Valium, Xanax, and Ativan.

Special information if you are pregnant or breastfeeding

The effects of Mirtazapine during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, tell your doctor immediately. It is not known whether Mirtazapine appears in breast milk. However, because many drugs do make their way into breast milk, you should tell your doctor if you are breastfeeding or plan to breastfeed.

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Recommended dosages of Mirtazapine

ADULTS

The usual starting dose is 15 milligrams taken daily before going to sleep. Depending upon your response, your dosage may be increased to as much as 45 milligrams a day.

CHILDREN

The safety and effectiveness of Mirtazapine have not been established in children.

Overdosage of Mirtazapine

Any medication taken in excess can have serious consequences. If you suspect an overdose of Mirtazapine, seek medical attention immediately.

Symptoms of Mirtazapine overdose include:
Drowsiness, impaired memory, mental confusion, rapid heartbeat

 

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